Friday, November 30, 2012

Marcy Miller: Internet Warfare

Being victimized by jealous women on the internet is not limited to generals and celebrities. I have also been the target of a cyber bully, and in my case, it was an ex-wife.

I had been dating a man who had recently begun the divorce process and had been living separately from his wife for about five months. We were fixed up by my good friend at a holiday party, and there was chemistry from the start. We began to date and spend time in my part of the city, while the soon-to-be-ex lived in another community about 40 minutes away. We never crossed paths or bumped into one another. As far as I was concerned, she was not even on my radar.

I had heard that she had anger issues and was not well-liked by his kids or his friends. I would joke that she was an easy act to follow, but she hardly seemed to be an issue for my date at all. The marriage had been over for some time and he just wanted to get on with his life.

One night, my date and I went to a movie and I left my cell phone in the car. When I returned, there were over 200 messages on my phone and more coming in. I was alarmed and began to read the texts. They were all from men, stating in various lewd references that they would love to have sex with me and wanted to come over ASAP. I was shocked. I had no idea where they came from and immediately called Verizon, but they were of no help.

Putting to use my best "Nancy Drew" investigative skills, I decided to call one of the men and ask where he had found my contact information. He told me that he was responding to my ad on Craigslist, and he gave me the number of the ad. I rushed home to look it up. There I was, a 36 DD horny Hispanic woman who just wanted to hook up at my house with no strings attached. My cell number was conveniently included.

My next call was to Craigslist, who immediately pulled the ad and were very cooperative. After a brief investigation, it turned out that my date's soon-to-be-ex had placed the ad from a friend's computer, thinking that she would never be traced. But since he did not want to get involved, the friend who owned the computer sang like a canary and ratted her out.

I was furious. I had nothing to do with the break-up of her marriage, so why was she targeting me? It was an attack on an innocent bystander. As a lawyer who believes in fair play, I decided to bring a lawsuit against her. My purpose in doing so was to teach her a lesson so that she would leave me and other future innocent women alone. Ultimately, I dropped any charges in exchange for a written admission of guilt and an apology from her and moved on.

I know how it feels to be harassed and abused on the internet. Divorce is rarely pretty, but it must not cast a broad net that hurts innocent victims. Technology is not a weapon to be used for amusement at someone else's expense.

?

"; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/marcy-miller/internet-warfare_b_2194790.html

Lisa Robin Kelly Jason Babin Zig Ziglar olivier martinez florida lotto ny lottery Ohio Lottery

Thursday, November 29, 2012

Invaluable Jason Witten Elite Jersey Website Marketing Techniques ...

It?s not sufficient these days just to put a web site Jason Witten Jersey online. With millions of sites previously present, if all you do is put up a site, you?re gonna have a problem bringing in anyone. The good news is, website marketing is available to help you customers to discover you on the web and tempt them to purchase from you. Below are a few best ways to advertise your organization on the net.

For successful website marketing, take advantage of social sites. Folks are checking these internet sites a lot more typically, easily using vouchers, bargains along with other information from accounts they stick to. Providing a simple, short information that gives insight or valuable vouchers will bring in people?s Jason Witten Jersey consideration.

If you use an email to communicate with your clients, ensure that it really is a skilled electronic mail accounts. You will nothing like the experience of obtaining an email from somebody you are contacting for job from a message coming from a free email site. Get an email that may be linked aimed at your website.

To begin on the way to good results online, make sure that you are customer targeted. It is because the requirements the buyers will determine what your business will give you. If you notice a need, you can see a marketplace chance. If your business is focused on gratifying which need, the target industry will give you business.

Convert your website on Jason Witten Jersey distinct vocabulary. If you plan on marketing your merchandise for an United states target audience only, you should continue to take into account converting your web site in Spanish language. On the other hand, you might widen your market place by selling your merchandise overseas. Engage a professional translator to convert your web site and get indigenous speakers enhance it.

While you develop and promote your brand online, find techniques to generate a single picture that extends to your logo design, website, wrapping and advertisements. An ongoing shade palette and steady typeface usage, could make your brand name and merchandise appear much more professional, respected and genuine. Will not involve neon or clashing colours in your marketing materials, simply because they are attention-obtaining. Include them, only when they are Jason Witten Elite Jersey element of your overall ?look?.

Fine-tuning the look of your web advertising internet site can result in a rise in income to your organization. Try out moving your ?Acquire Now? key to another spot to ascertain if it gets far more use. Determine if an alternative shade system triggers your customers to remain a little longer on your own web site.

Test out your site like it really is a merchandise. In other words, usually do not slack off on ensuring that the hyperlinks job, the internet site is user-friendly, and this it seems how you will want it to. It can not be stressed enough that for anyone to return, you have to Jason Witten Nike Jersey give them reasons to.

Internet marketing may take you an undetected no person to the most common internet site inside your industry. You need to simply just work at it. Follow these tips to get moving, and you will commence to see effects that may prove how helpful website marketing may be for your business.

Authorised Tony Romo Jersey Shop shows a lot of low cost Sean Lee Jersey straight away with Super fast Distribution, Score Checkout & Great Customer Care.

Related posts:

  1. Internet Marketing Jason Witten Elite Jersey Simple Suggestions That Every Business Requires
  2. Are You Jason Witten Elite Jersey Misplaced At How To Start With Website Marketing? Start Right here Using This Good Advice
  3. Highly effective Jason Witten Elite Jersey And Useful Web Marketing Ideas And Creativity
  4. World Wide Jason Witten Nike Jersey Wow: Website Marketing Ideas To Try out These days
  5. Things To Jason Witten Jersey Consider For Your Personal Web Marketing Method

Source: http://www.hugohosting.com/invaluable-jason-witten-elite-jersey-website-marketing-techniques-for-your-business.html

do not call list sports illustrated westminster dog show 2012 words with friends words with friends phlebotomy dog show

#asus , 14:35PT update (+photo): Asus Transformer Book with Intel core i7 and windows 8...

Sorry, Readability was unable to parse this page for content.

Source: http://live.ubergizmo.com/us/2012/10/asus-1435pt-update-photo-asus-transformer-book-with-intel-core-i7-and-windows-8.html

News Nate Silver stock market stock market Google News Obama Acceptance Speech 2012 alabama football

President Obama a Clear Winner for Women


President Obama fought for women?s rights ? both pay equity and reproductive rights ? for immigrant rights, and for working people.? The President fought for education opportunity, teachers, a robust economy and his leadership that does not leave women behind. President Obama made it clear that Romney sought to cut off funding to Planned Parenthood and women?s rights to make their own medical decisions.? President repeatedly called out Romney when he twisted the facts. Moreover the President stood strongly with his Secretary of State Hillary Clinton? and his diplomatic team as Governor Romney tried to score political points on the tragic attack on our heroic Ambassador and his courageous staff.

Once again the woman moderator, this time Candy Crowley, just like Martha Raddatz for the vice presidential debate, showed her strength as well as her knowledge of political affairs.? Crowley was the first women to moderator a presidential debate in some 20 years. This time lapse must not happen again.? But the audience appeared to be disproportionally white men.

Source: http://feedproxy.google.com/~r/FeministsForObama/~3/6X-QGltZz_c/

delilah nevis 2012 sports illustrated swimsuit same day flower delivery valentines day westminster dog show valentines day cards

Historical society hopes to reopen Conser Home - News9.com ...

HEAVENER, Okla. (AP) - The Oklahoma Historical Society says it plans to reopen the historic Peter Conser Home next spring.

The historic site in southeast Oklahoma has been closed to the public because of increased costs and budget cuts. Officials say Conser's family donated the property to the Oklahoma Historical Society with the stipulation that it be operated as a museum. If not, the property would revert back to the family.

Kathy Dickson, the society's director of museums and historic sites, says the society is working with members of the Conser family to reopen the home.

A meeting is planned for Dec. 12 in Heavener to discuss the issue.

Peter Conser was born in the mid-19th century in McCurtain County. He is best known as a member of the Choctaw Nation's famed Lighthorsemen.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.news9.com/story/20207829/historical-society-hopes-to-reopen-conser-home

ohio primary cell phone jammer g8 summit netanyahu aipac vanessa minnillo super tuesday

Logistics, GIS and Disaster Response | GPS World

A 40-foot recreation of a 19th-century lighthouse rises inside the atrium of Lockheed Martin?s Center for Innovation.

An exercise in planning for months proves timely in light of Hurricane Sandy

By Art Kalinski

I was going to write about the increasing presence of social media at GEOINT 2012, but I?ll cover that next month since Hurricane Sandy made an exercise I attended last week more significant in its timeliness.

The Disaster Response Integrative Logistics Exercise was a joint effort of the Institute for Defense & Business and Lockheed Martin. Heading up the effort was retired U.S. Ambassador David Litt of the IDB and Corey Cook of Lockheed Martin. The almost week-long event was held at the Lockheed Martin Lighthouse located in Suffolk, Virginia, near Norfolk. The 65,000-square-foot high-technology facility is designed for experimentation and prototyping using analysis, modeling and simulation. It?s a reconfigurable command and control operations laboratory that permits participants to test and analyze concepts in a gaming environment.

The stated purpose of the disaster response exercise was: ?Given the nature, frequency, location and severity of disasters, inter-organizational collaboration ? to include the private sector ? is becoming increasingly critical to the efficiency and effectiveness of logistics in disaster responses.?? The exercise involved more than a 100 participants from the private sector, government agencies, non-profit organizations, and military services. Lou Kratz, Vice president and managing director, Logistics and Sustainment, Corporate Engineering & Technology for Lockheed Martin, stated that ?Today?s crisis response efforts struggle with effective collaboration among participating organizations, especially in the domain of logistics. This trend cannot continue in an era of 21st-century logistics capabilities. With global resources available from public sector and private organizations, we all need to collaborate effectively to help our communities and businesses recover.?

The Lockheed Martin Lighthouse in Suffolk, Virginia, site of the Disaster Response Integrative Logistics Exercise.

And collaborate we did! The list of participants was quite extensive and quite diverse. To give you a sense of the attendees, here is a partial list of organizations represented:

  • commercial companies included DHL, Maersk, Florida Power and Light, Fluor, Home Depot, Walmart
  • federal government agencies included FEMA, DHS, GSA, HHS, USAID, State Department
  • military organizations included NAVSUP, NORTHCOM, USACE, USAF, USMC, USN, SOUTHCOM, National Defense University, USCG, NORTHCOM
  • NGOs included United Nations agencies, the Red Cross, Operation Blessing, Catholic Relief Services and many more.

Conference attendance was significantly impacted by Hurricane Sandy, which also highlighted its timeliness.? FEMA, USAID, USACE, and the Red Cross, who were confirmed attendees and were instrumental in the development of the DRIL exercise, were deployed to Hurricane Sandy just hours before the start of the event. Fortunately, attendance to the DRIL by multiple organizations and substitute personnel was still robust, allowing for a highly successful exercise.

The DRIL exercise had robust attendance despite Hurricane Sandy.

Some of the exercise objectives included defining and understanding different agency logistics capabilities, leadership structures, institutional and regulatory obstacles, differences in cultures, missions and operating procedures while developing metrics to evaluate performance in disaster response efforts. To accomplish the objectives, all the participants were organized into four integrated teams that were then separated at times into functional teams and then reassembled with representatives speaking for each team to the entire group of attendees.

Since this was the first exercise of its type, it was a learning experience for all involved and focused on the basics of personnel interactions and group consensus.? Each participant had access to his or her own computer, common computer resources and pre-developed exercise parameters. There were many artificial assumptions presented to the teams, and the team members made even more assumptions and guesses as they worked through the individual scenarios. Most of the exercise consisted of reviewing the effects of Category 5 hurricanes hitting the Dominican Republic, South Florida and Virginia, so there was a domestic as well as international impact. We participated in our groups, listening to individual team members with specialized knowledge and experience, then prioritized the delivery of needed resources and services. As the exercises ramped up, there were many animated discussions in which basics such as water, food, shelter, medical, electric power and transportation infrastructure were prioritized and justification documented.

I made several observations to myself as the exercises progressed. First, there are definite cultural differences between federal, military, NGO and commercial agencies. Not bad differences, just different. Second, individual personalities can steer the group dynamics and outcomes. And third, situational awareness is critical to effective disaster response. Geospatial technology was not part of this first exercise, but would clearly have been valuable to provide a common operational picture. That level of complexity would not have been practical for this initial exercise, but it does lead me to the ?Solutions? room next to the main exercise area.

In a space adjacent to the main exercise room was a ?Solutions? room that showcased potentially helpful technologies. The room was open to exercise participants toward the tail end of the week. It consisted of a diverse assortment of commercial and government solutions that addressed some of the issues? the teams struggled with during the week. Examples include a new computer-based system developed by the Navy Supply Systems Command (NAVSUP) that is similar to the commercial Kayak flight search system. The Transportation Exploitation Tool (TET) was explained to me by Greg Butler, division director, NAVSUP GLS Transportation, who initiated the effort. He explained that all too often resources are wasted flying parts or personnel on dedicated aircraft that are duplicate trips of other aircraft or ships with available space traveling to the same location. The new geospatial network scheduling system optimizes transportation resources across all branches of service and already saved the Navy $23M on a $750k investment.

Lockheed Martin?s Hybrid Air Vehicle is a multi-mission capable airship.

Lockheed Martin displayed several technologies, including communications and data management technologies. One of the most interesting was its Hybrid Aircraft that was initially developed for military use. However, its ability to transport equipment and supplies efficiently to undeveloped sites while providing a persistent platform for communications and to collect and download imagery makes it a valuable asset for emergency response activities.? To learn more, view the following video.

A representative from NATO explained the NATO Civil-Military Fusion Center, including a map library and custom services. Several exhibitors demonstrated the use of social media, which can be a very valuable and timely source of information to build situational awareness during emergencies. A company I work with, Soft Power Solutions, integrates GIS resources such as Google, USGS, ortho and oblique imagery married to geographically placed social media to build situational awareness that is quite robust. It was especially dramatic that during demonstrations, a 7.2 earthquake was reported off the coast of Guatemala.? One could easily see the growing number of tweets that almost immediately confirmed the earthquake and level of damage. Here is a ShakeMap generated by USGS within minutes of the earthquake showing the level of impact on the Guatemalan coast (shown in yellow).

A USGS ShakeMap shows the impact of an earthquake on the Guatemalan coast (in yellow).

One of the exercise objectives was to develop metrics that would evaluate performance in disaster response efforts. There were many metrics developed that one would expect ? roads open, electricity restored, utilities restored, etc. However, the one informal metric that was developed through personal experience of Florida emergency responders was the ?Waffle House? metric. Waffle House is a ubiquitous restaurant chain with locations throughout the southeast. The Florida responders observed that driving from one county?s Waffle House to another open Waffle House was a good indicator that the location was in OK shape.? Since a Waffle House needs minimal staffing and utilities compared to larger restaurants, it was a good indicator as to how bad conditions were in the location. Perhaps someone will develop a ?Waffle House Open? type GIS layer as a metric to ?okayness.?? Sounds like a good thesis for a GIS graduate student.

Everyone who participated was enthusiastic about conducting another similar exercise. Planning is already underway to make that happen. I, for one, feel that this kind of exercise can have a significant positive impact on future disasters because it builds face-to-face relationships that are so valuable during actual events. I?m going to do what I can to help with a geospatial aspect in future exercises.

Written by: GPS World staff on November 27, 2012.
Last revised by: bchambers
November 28, 2012.

Source: http://www.gpsworld.com/logistics-gis-and-disaster-response/

grammys album of the year grammy red carpet grammy award winners the band perry grammy awards whitney houston autopsy

Wednesday, November 28, 2012

Video: Arafat exhumation could raise more questions than answers



>>> also in the middle east today, they took an extraordinary step to investigate an old rumor, they dug up the body of yasser arafat to see if he had been poisoned, and they're conducting tissue samples all over the world now to find out. we get our report from our veteran middle eastern correspondent martin fletcher in ramallah .

>> reporter: a grim day in ramallah , yasser arafat was reburied after scientists took samples from his remains, seeking an answer to the mystery that began with his death eight years ago. was he murdered? palestinians may soon have an answer. labs in russia, france and switzerland will conduct separate tests of bone samples taken today. muslim clerics gave permission to open his grave. it was a delicate process kept out of sight.

>> it was important for the palestinians to emphasize that no hands touch the remains of yasser arafat . only the palestinians touched him. a matter of honor.

>> the last time arafat was seen in public he flew to a paris hospital age 75 and sick. three weeks later he was dead. why? his wife refused an autopsy. rumors flew, aids murdered, poisoned, that's what many palestinians believed.

>> all the circumstantial evidence , all the political evidence indicates one direction, which is mr. sharon.

>> reporter: there is no evidence he had been killed until this year. the investigation was triggered by swiss technicians working with al jazeera tv . they examined arafat's toothbrush and hat. and found traces of radioactive pe pelonium 210. the question now is, will they find it on his bones.

>> the idea of being able to detect pelonium 210 this long after burial is low.

>> reporter: the test could raise more questions than it answers. yasser arafat controversial in life, his death still a riddle. martin fletcher , nbc news, ramallah , the west bank .

Source: http://video.msnbc.msn.com/nightly-news/49986366/

chris kreider correspondents dinner 2012 white house correspondents dinner 2012 whcd 2012 nfl draft kevin durant jazz fest

Tuesday, November 27, 2012

Cyber Monday likely to be busiest online sales day

(AP) ? Black Friday is a distant memory. Small Business Saturday is long gone. Now, it's Cyber Monday's turn.

Cyber Monday, coined in 2005 by a shopping trade group that noticed a spike in online sales on the Monday after Thanksgiving when people returned to their work computers, is the next in a line of days that stores are counting on to jumpstart the holiday shopping season.

This year's Cyber Monday is expected to be the biggest online shopping day of the year for the third year in a row: According to research firm comScore, Americans are expected to spend $1.5 billion, up from $1.25 billion last year on Cyber Monday, as retailers ramp up deals to get shoppers to click on their websites.

Amazon.com, which is starting its Cyber Monday deals at midnight on Monday, is offering as much as 60 percent off a Panasonic VIERA 55-inch TV that's usually priced higher than $1,000. Sears is offering $430 off a Maytag washer and dryer, each on sale for $399. And Kmart is offering 75 percent off diamond earrings and $60 off a 12-in-1 multigame table on sale for $89.99.

Retailers are hoping the deals will appeal to shoppers like Matt Sexton, 39, who for the first time plans to complete all his holiday shopping online this year on his iPad tablet computer. Sexton, who plans to spend up to $4,000 this season, already shopped online on the day after Thanksgiving known as Black Friday and found a laptop from Best Buy for $399, a $200 savings, among other deals.

"The descriptions and reviews are so much better online so you can compare and price shop and for the most part get free shipping," said Sexton, who lives in Queens, N.Y., and is a manager at a utility company.

Sexton also said it's easy to return an online purchase to a physical store than it had been in previous years. "That helps with gifts," he said.

How well retailers do on Cyber Monday will offer insight into Americans' evolving shopping habits. With the growth in high speed Internet access and the wide and increasing use of smartphones and tablet computers, people are relying less on their work computers to shop than they did when Shop.org, the digital division of trade group The National Retail Federation, coined the term "Cyber Monday."

As a result, the period between Thanksgiving and Cyber Monday has have become busy for online shopping as well. Indeed, IBM Benchmark, which tracks online sales, said on Thanksgiving, a day that historically had not been big for online shopping, online sales this year rose 17.4 percent over 2011. Of that, mobile shopping, or shopping on smartphones and tablets, rose 18.3 percent. Meanwhile, online sales on Black Friday were up 20.7 percent.

For the overall holiday season, comScore predicts online sales will be up 17 percent to $43.4 billion. And the research firm expects online sales to surpass 10 percent of total retail spending this holiday season. The National Retail Federation estimates that overall retail sales in November and December will be up 4.1 percent this year to $586.1 billion

"People years ago didn't have the kind of connectivity to shop online at their homes. So when they went back to work after Thanksgiving they'd shop on the Monday after," said Vicki Cantrell, executive director of Shop.org. "Now they don't need the work computer to be able to do that."

But as other days become popular for online shopping, Cyber Monday may lose some of its cache. To be sure, Cyber Monday hasn't always been the biggest online shopping day. In fact, up until three years ago, that title was historically held on the last day shoppers can order items with standard shipping rates and get them delivered before Christmas. That day usually falls in late December.

Even though Cyber Monday is expected to be the biggest shopping day this year, industry watchers say it could just be a matter of time before other days take that ranking.

"Of all the benchmark spending days, Thanksgiving is growing at the fastest rate, up 128 percent over the last five years," said Andrew Lipsman, a spokesman with comScore.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-11-25-Cyber%20Monday/id-0dd269847fed441fb743d32221b81871

in plain sight hunger games movie review bats

Monday, November 26, 2012

ScienceDaily: Gene News

ScienceDaily: Gene Newshttp://www.sciencedaily.com/news/health_medicine/genes/ Genes and Genetics News. Read today's medical research in genetics including what can damage genes, what can protect them, and more.en-usSun, 25 Nov 2012 21:51:11 ESTSun, 25 Nov 2012 21:51:11 EST60ScienceDaily: Gene Newshttp://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/health_medicine/genes/ For more science articles, visit ScienceDaily.Transposable elements reveal a stem cell specific class of long noncoding RNAshttp://www.sciencedaily.com/releases/2012/11/121125192838.htm Over a decade after sequencing the human genome, it has now become clear that the genome is not mostly ?junk? as previously thought. In fact, the ENCODE project consortium of dozens of labs and petabytes of data have determined that these ?noncoding? regions house everything from disease trait loci to important regulatory signals, all the way through to new types of RNA-based genes.Sun, 25 Nov 2012 19:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121125192838.htmNew molecular culprit linked to breast cancer progressionhttp://www.sciencedaily.com/releases/2012/11/121124090511.htm Researchers have uncovered a protein ?partner? commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery details how some tumors get the tools they need to metastasize.Sat, 24 Nov 2012 09:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121124090511.htmNew insights into virus proteome: Unknown proteins of the herpesvirus discoveredhttp://www.sciencedaily.com/releases/2012/11/121123092132.htm The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system scientists have shown that the genome of this virus contains much more information than previously assumed. The researchers identified several hundred novel proteins, many of which were surprisingly small.Fri, 23 Nov 2012 09:21:21 ESThttp://www.sciencedaily.com/releases/2012/11/121123092132.htmScientists describe elusive replication machinery of flu viruseshttp://www.sciencedaily.com/releases/2012/11/121122152928.htm Scientists have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to ?see? one of influenza?s essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus?s vulnerabilities that are sure to be of interest to drug developers.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152928.htmProtein folding: Look back on scientific advances made as result of 50-year old puzzlehttp://www.sciencedaily.com/releases/2012/11/121122152910.htm Fifty years after scientists first posed a question about protein folding, the search for answers has led to the creation of a full-fledged field of research that led to major advances in supercomputers, new materials and drug discovery, and shaped our understanding of the basic processes of life, including so-called "protein-folding diseases" such as Alzheimer's, Parkinson's and type II diabetes.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152910.htmStep forward in regenerating and repairing damaged nerve cellshttp://www.sciencedaily.com/releases/2012/11/121121145638.htm Researchers recently uncovered a nerve cell's internal clock, used during embryonic development. This breakthrough could lead to the development of new tools to repair and regenerate nerve cells following injuries to the central nervous system.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145638.htmArchitecture of rod sensory cilium disrupted by mutationhttp://www.sciencedaily.com/releases/2012/11/121121145621.htm Using a new technique called cryo-electron tomography, scientists have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of photoreceptor in the eye) is changed by genetic mutation and how that affects its ability to transport proteins as part of the light-sensing process.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145621.htmAging: Scientists further unravel telomere biologyhttp://www.sciencedaily.com/releases/2012/11/121121130933.htm Researchers have resolved the structure of that allows a telomere-related protein, Cdc13, to form dimers in yeast. Mutations in this region of Cdc13 put the kibosh on the ability of telomerase and other proteins to maintain telomeres.Wed, 21 Nov 2012 13:09:09 ESThttp://www.sciencedaily.com/releases/2012/11/121121130933.htmDrug resistance biomarker could improve cancer treatmenthttp://www.sciencedaily.com/releases/2012/11/121121130811.htm Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reported in a new study. The study reveals a biomarker that can predict responses to cancer drugs and offers a strategy to treat drug-resistant tumors based on their genetic signature.Wed, 21 Nov 2012 13:08:08 ESThttp://www.sciencedaily.com/releases/2012/11/121121130811.htmGenome packaging: Key to breast cancer developementhttp://www.sciencedaily.com/releases/2012/11/121121130703.htm Two recent studies delve into the role of chromatin modifying enzymes and transcription factors in tumour cells. In one, it was found that the PARP1 enzyme activated by kinase CDK2 is necessary to induce the genes responsible for the proliferation of breast cancer cells in response to progesterone. In another, extensive work has been undertaken to identify those genes activated by the administration of progesterone in breast cancer, the sequences that can be recognized and how these genes are induced.Wed, 21 Nov 2012 13:07:07 ESThttp://www.sciencedaily.com/releases/2012/11/121121130703.htmShort DNA strands in genome may be key to understanding human cognition and diseaseshttp://www.sciencedaily.com/releases/2012/11/121121130643.htm Previously discarded, human-specific ?junk? DNA represents untapped resource in the study of diseases like Alzheimer?s and autism.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130643.htmBiomarking time: Methylome modifications offer new measure of our 'biological' agehttp://www.sciencedaily.com/releases/2012/11/121121130633.htm In a new study, researchers describe markers and a model that quantify how aging occurs at the level of genes and molecules, providing not just a more precise way to determine how old someone is, but also perhaps anticipate or treat ailments and diseases that come with the passage of time.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130633.htmKidney tumors have a mind of their ownhttp://www.sciencedaily.com/releases/2012/11/121121104552.htm New research has found there are several different ways that kidney tumors can achieve the same result -- namely, grow.Wed, 21 Nov 2012 10:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121121104552.htmMechanism to repair clumped proteins explainedhttp://www.sciencedaily.com/releases/2012/11/121121104416.htm Clumped proteins can be dissolved with the aid of cellular repair systems -- a process of critical importance for cell survival especially under conditions of stress. Researchers have now decrypted the fundamental mechanism for dissolving protein aggregates that involves specific molecular chaperones.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104416.htmNovel mechanism through which normal stromal cells become cancer-promoting stromal cells identifiedhttp://www.sciencedaily.com/releases/2012/11/121121104401.htm New understanding of molecular changes that convert harmless cells surrounding ovarian cancer cells into cells that promote tumor growth and metastasis provides potential new therapeutic targets for this deadly disease, according to new research.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104401.htmNew test for tuberculosis could improve treatment, prevent deaths in Southern Africahttp://www.sciencedaily.com/releases/2012/11/121120194932.htm A new rapid test for tuberculosis (TB) could substantially and cost-effectively reduce TB deaths and improve treatment in southern Africa -- a region where both HIV and tuberculosis are common.Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194932.htmEvolution of human intellect: Human-specific regulation of neuronal geneshttp://www.sciencedaily.com/releases/2012/11/121120194926.htm A new study has identified hundreds of small regions of the genome that appear to be uniquely regulated in human neurons. These regulatory differences distinguish us from other primates, including monkeys and apes, and as neurons are at the core of our unique cognitive abilities, these features may ultimately hold the key to our intellectual prowess (and also to our potential vulnerability to a wide range of 'human-specific' diseases from autism to Alzheimer's).Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194926.htmRibosome regulates viral protein synthesis, revealing potential therapeutic targethttp://www.sciencedaily.com/releases/2012/11/121120132906.htm Rather than target RNA viruses directly, aiming at the host cells they invade could hold promise, but any such strategy would have to be harmless to the host. Now, a surprising discovery made in ribosomes may point the way to fighting fatal viral infections such as rabies.Tue, 20 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121120132906.htmHow does antibiotic resistance spread? Scientists find answers in the nosehttp://www.sciencedaily.com/releases/2012/11/121120121835.htm Microbiologists studying bacterial colonization in mice have discovered how the very rapid and efficient spread of antibiotic resistance works in the respiratory pathogen, Streptococcus pneumoniae (also known as the pneumococcus). The team found that resistance stems from the transfer of DNA between bacterial strains in biofilms in the nasopharynx, the area just behind the nose.Tue, 20 Nov 2012 12:18:18 ESThttp://www.sciencedaily.com/releases/2012/11/121120121835.htmScientists identify inhibitor of myelin formation in central nervous systemhttp://www.sciencedaily.com/releases/2012/11/121120100155.htm Scientists have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system. Myelin promotes the conduction of nerve cell impulses by forming a sheath around their projections, the so-called axons, at specific locations -- acting like the plastic insulation around a power cord.Tue, 20 Nov 2012 10:01:01 ESThttp://www.sciencedaily.com/releases/2012/11/121120100155.htm'Obese but happy gene' challenges the common perception of link between depression and obesityhttp://www.sciencedaily.com/releases/2012/11/121120084725.htm Researchers have discovered new genetic evidence about why some people are happier than others. The scientists have uncovered evidence that the gene FTO -- the major genetic contributor to obesity -- is associated with an eight per cent reduction in the risk of depression. In other words, it's not just an obesity gene but a "happy gene" as well.Tue, 20 Nov 2012 08:47:47 ESThttp://www.sciencedaily.com/releases/2012/11/121120084725.htmTelomere lengths predict life expectancy in the wild, research showshttp://www.sciencedaily.com/releases/2012/11/121119213144.htm Researchers have found that biological age and life expectancy can be predicted by measuring an individual's DNA. They studied the length of chromosome caps -- known as telomeres -- in a 320-strong wild population of Seychelles Warblers on a small isolated island.Mon, 19 Nov 2012 21:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121119213144.htmCancer: Some cells don't know when to stophttp://www.sciencedaily.com/releases/2012/11/121119171403.htm Certain mutated cells keep trying to replicate their DNA -- with disastrous results -- even after medications rob them of the raw materials to do so, according to new research.Mon, 19 Nov 2012 17:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121119171403.htmMultiple sclerosis ?immune exchange? between brain and blood is uncoveredhttp://www.sciencedaily.com/releases/2012/11/121119163301.htm DNA sequences obtained from a handful of patients with multiple sclerosis have revealed the existence of an ?immune exchange? that allows the disease-causing cells to move in and out of the brain.Mon, 19 Nov 2012 16:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121119163301.htmFruit fly studies guide investigators to molecular mechanism frequently misregulated in human cancershttp://www.sciencedaily.com/releases/2012/11/121119132056.htm Changes in how DNA interacts with histones ?- the proteins that package DNA ?- regulate many fundamental cell activities from stem cells maturing into a specific body cell type or blood cells becoming leukemic. These interactions are governed by a biochemical tug of war between repressors and activators, which chemically modify histones signaling them to clamp down tighter on DNA or move aside and allow a gene to be expressed.Mon, 19 Nov 2012 13:20:20 ESThttp://www.sciencedaily.com/releases/2012/11/121119132056.htm3-D light switch for the brain: Device may help treat Parkinson's, epilepsy; aid understanding of consciousnesshttp://www.sciencedaily.com/releases/2012/11/121119114249.htm A new tool for neuroscientists delivers a thousand pinpricks of light to individual neurons in the brain. The new 3-D "light switch", created by biologists and engineers, could one day be used as a neural prosthesis that could treat conditions such as Parkinson's and epilepsy by using gene therapy to turn individual brain cells on and off with light.Mon, 19 Nov 2012 11:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121119114249.htmNew factor of genetic susceptibility to Alzheimer's diseasehttp://www.sciencedaily.com/releases/2012/11/121119104944.htm A large-scale international study has just discovered a gene for susceptibility to a rare disease providing evidence of the heterogeneous aetiology of Alzheimer's disease.Mon, 19 Nov 2012 10:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121119104944.htmBlood cancer gene BCL6 identified as a key factor for differentiation of nerve cells of cerebral cortexhttp://www.sciencedaily.com/releases/2012/11/121119093848.htm The cerebral cortex is the most complex structure in our brain and the seat of consciousness, emotion, motor control and language. In order to fulfill these functions, it is composed of a diverse array of nerve cells, called cortical neurons, which are affected by many neurological and neuropsychiatric diseases. Researchers have opened new perspectives on brain development and stem cell neurobiology by discovering a gene called BCL6 as a key factor in the generation of cortical neurons during embryonic brain development.Mon, 19 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121119093848.htmMinority report: Insight into subtle genomic differences among our own cellshttp://www.sciencedaily.com/releases/2012/11/121118141530.htm Scientists have demonstrated that induced pluripotent stem cells -- the embryonic-stem-cell look-alikes whose discovery a few years ago won this year's Nobel Prize in medicine -- are not as genetically unstable as was thought.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141530.htmSkin cells reveal DNA's genetic mosaichttp://www.sciencedaily.com/releases/2012/11/121118141524.htm The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141524.htmLikely basis of birth defect causing premature skull closure in infants identifiedhttp://www.sciencedaily.com/releases/2012/11/121118141432.htm Geneticists, pediatricians, surgeons and epidemiologists have identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis premature closure of the bony plates of the skull.Sun, 18 Nov 2012 14:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121118141432.htmDNA packaging discovery reveals principles by which CRC mutations may cause cancerhttp://www.sciencedaily.com/releases/2012/11/121117184658.htm A new discovery concerning a fundamental understanding about how DNA works will produce a "180-degree change in focus" for researchers who study how gene packaging regulates gene activity, including genes that cause cancer and other diseases.Sat, 17 Nov 2012 18:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121117184658.htmHepatitis C treatment's side effects can now be studied in the labhttp://www.sciencedaily.com/releases/2012/11/121116161059.htm Adverse side effects of certain hepatitis C medications can now be replicated in the lab, thanks to a research team. The new method aids understanding of recent failures of hepatitis C antiviral drugs in some patients, and could help to identify medications that eliminate adverse effects. The findings may aid the development of safer and more effective treatments for hepatitis C and other pathogens such as SARS and West Nile virus.Fri, 16 Nov 2012 16:10:10 ESThttp://www.sciencedaily.com/releases/2012/11/121116161059.htmReconsidering cancer's bad guyhttp://www.sciencedaily.com/releases/2012/11/121116124644.htm Researchers have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain.Fri, 16 Nov 2012 12:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121116124644.htmGene distinguishes early birds from night owls and helps predict time of deathhttp://www.sciencedaily.com/releases/2012/11/121116124551.htm New research shows that a gene is responsible for a person's tendency to be an early riser or night owl -- and helps determine the time of day a person is most likely to die.Fri, 16 Nov 2012 12:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121116124551.htmClues to cause of kids' brain tumorshttp://www.sciencedaily.com/releases/2012/11/121116091226.htm Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children.Fri, 16 Nov 2012 09:12:12 ESThttp://www.sciencedaily.com/releases/2012/11/121116091226.htmArthritis study reveals why gender bias is all in the geneshttp://www.sciencedaily.com/releases/2012/11/121115210541.htm Researchers have pieced together new genetic clues to the arthritis puzzle in a study that brings potential treatments closer to reality and could also provide insights into why more women than men succumb to the disabling condition.Thu, 15 Nov 2012 21:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121115210541.htmClass of RNA molecules protects germ cells from damagehttp://www.sciencedaily.com/releases/2012/11/121115172255.htm Passing one's genes on to the next generation is a mark of evolutionary success. So it makes sense that the body would work to ensure that the genes the next generation inherits are exact replicas of the originals. Biologists have now identified one way the body does exactly that.Thu, 15 Nov 2012 17:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121115172255.htmQuick test speeds search for Alzheimer's drugs: Compound restores motor function and longevity to fruit flieshttp://www.sciencedaily.com/releases/2012/11/121115152655.htm Researchers report that an efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease.Thu, 15 Nov 2012 15:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115152655.htmProtein-making machinery can switch gears with a small structural change process; Implications for immunity and cancer therapyhttp://www.sciencedaily.com/releases/2012/11/121115133414.htm For the past several years, research has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process of producing proteins. In a new study, scientists have shown that this enzyme can actually also work in another fundamental process in humans.Thu, 15 Nov 2012 13:34:34 ESThttp://www.sciencedaily.com/releases/2012/11/121115133414.htmPlant derivative, tanshinones, protects against sepsis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121115133312.htm Researchers have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis.Thu, 15 Nov 2012 13:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121115133312.htmStructure of enzyme topoisomerase II alpha unravelled providing basis for more accurate design of chemotherapeutic drugshttp://www.sciencedaily.com/releases/2012/11/121115132903.htm Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are important enzymes that are involved in maintaining the structure of DNA and chromosome segregation during both replication and transcription of DNA. One of these enzymes, topoisomerase II alpha, is involved in the replication of DNA and cell proliferation, and is highly expressed in rapidly dividing cancer cells.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132903.htmNewly discovered enzyme important in the spreading of cancerhttp://www.sciencedaily.com/releases/2012/11/121115132901.htm Enzyme hunters at UiO have discovered the function of an enzyme that is important in the spreading of cancer. Cancer researchers now hope to inhibit the enzyme.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132901.htmGenetics point to serious pregnancy complication, pre-eclampsiahttp://www.sciencedaily.com/releases/2012/11/121115132613.htm New research has revealed a genetic link in pregnant moms - and their male partners - to pre-eclampsia, a life-threatening complication during pregnancy.Thu, 15 Nov 2012 13:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115132613.htmMolecular mechanisms underlying stem cell reprogramming decodedhttp://www.sciencedaily.com/releases/2012/11/121115132344.htm Thanks to some careful detective work, scientist better understand just how iPS cells form ? and why the Yamanaka process is inefficient, an important step to work out for regenerative medicine. The findings uncover cellular impediments to iPS cell development that, if overcome, could dramatically improve the efficiency and speed of iPS cell generation.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132344.htmSurprising genetic link between kidney defects and neurodevelopmental disorders in kidshttp://www.sciencedaily.com/releases/2012/11/121115132342.htm About 10 percent of kids born with kidney defects have large alterations in their genomes known to be linked with neurodevelopmental delay and mental illness, a new study has shown.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132342.htmEven moderate drinking in pregnancy can affect a child's IQhttp://www.sciencedaily.com/releases/2012/11/121114172833.htm Relatively small levels of exposure to alcohol while in the womb can influence a child's IQ, according to a new study using data from over 4,000 mothers and their children.Wed, 14 Nov 2012 17:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121114172833.htmGene nearly triples risk of Alzheimer's, international research team findshttp://www.sciencedaily.com/releases/2012/11/121114171710.htm A gene so powerful it nearly triples the risk of Alzheimer's disease has been discovered by an international team of researchers. It is the most potent genetic risk factor for Alzheimer's identified in the past 20 years.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171710.htmDiscovery could lead to faster diagnosis for some chronic fatigue syndrome caseshttp://www.sciencedaily.com/releases/2012/11/121114171708.htm For the first time, researchers have landed on a potential diagnostic method to identify at least a subset of patients with chronic fatigue syndrome - testing for antibodies linked to latent Epstein-Barr virus reactivation.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171708.htmResearch breakthrough could halt melanoma metastasis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121114153227.htm In laboratory experiments, scientists have eliminated metastasis, the spread of cancer from the original tumor to other parts of the body, in melanoma by inhibiting a protein known as melanoma differentiation associated gene-9 (mda-9)/syntenin.Wed, 14 Nov 2012 15:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114153227.htmPig genomes provide massive amount of genomic data for human healthhttp://www.sciencedaily.com/releases/2012/11/121114134512.htm Researchers provide a whole-genome sequence and analysis of number of pig breeds, including a miniature pig that serves a model for human medical studies and therapeutic drug testing.Wed, 14 Nov 2012 13:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121114134512.htmRare parasitic fungi could have anti-flammatory benefitshttp://www.sciencedaily.com/releases/2012/11/121114134054.htm Caterpillar fungi are rare parasites found on hibernating caterpillars in the mountains of Tibet. For centuries they have been highly prized as a traditional Chinese medicine - just a small amount can fetch hundreds of dollars.Wed, 14 Nov 2012 13:40:40 ESThttp://www.sciencedaily.com/releases/2012/11/121114134054.htmCancer therapy: Nanokey opens tumors to attackhttp://www.sciencedaily.com/releases/2012/11/121114113803.htm There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart of the target.Wed, 14 Nov 2012 11:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121114113803.htmHigh sperm DNA damage a leading cause of 'unexplained infertility', research findshttp://www.sciencedaily.com/releases/2012/11/121114113235.htm New research has uncovered the cause of infertility for 80 per cent of couples previously diagnosed with 'unexplained infertility': high sperm DNA damage.Wed, 14 Nov 2012 11:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114113235.htmA risk gene for cannabis psychosishttp://www.sciencedaily.com/releases/2012/11/121114083928.htm The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.Wed, 14 Nov 2012 08:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121114083928.htmBacterial DNA sequence used to map an infection outbreakhttp://www.sciencedaily.com/releases/2012/11/121113214635.htm For the first time, researchers have used DNA sequencing to help bring an infectious disease outbreak in a hospital to a close. Researchers used advanced DNA sequencing technologies to confirm the presence of an ongoing outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a Special Care Baby Unit in real time. This assisted in stopping the outbreak earlier, saving possible harm to patients. This approach is much more accurate than current methods used to detect hospital outbreaks.Tue, 13 Nov 2012 21:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121113214635.htmGenetic variation may modify associations between low vitamin D levels and adverse health outcomeshttp://www.sciencedaily.com/releases/2012/11/121113161506.htm Findings from a study suggest that certain variations in vitamin D metabolism genes may modify the association of low serum 25-hydroxyvitamin D concentrations with health outcomes such as hip fracture, heart attack, cancer, and death.Tue, 13 Nov 2012 16:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121113161506.htmNew type of bacterial protection found within cells: Novel immune system response to infections discoveredhttp://www.sciencedaily.com/releases/2012/11/121113143656.htm Biologists have discovered that fats within cells store a class of proteins with potent antibacterial activity, revealing a previously unknown type of immune system response that targets and kills bacterial infections.Tue, 13 Nov 2012 14:36:36 ESThttp://www.sciencedaily.com/releases/2012/11/121113143656.htmGlutamate neurotransmission system may be involved with depression riskhttp://www.sciencedaily.com/releases/2012/11/121113134807.htm Researchers using a new approach to identifying genes associated with depression have found that variants in a group of genes involved in transmission of signals by the neurotransmitter glutamate appear to increase the risk of depression.Tue, 13 Nov 2012 13:48:48 ESThttp://www.sciencedaily.com/releases/2012/11/121113134807.htmTargeting downstream proteins in cancer-causing pathway shows promise in cell, animal modelhttp://www.sciencedaily.com/releases/2012/11/121113134230.htm The cancer-causing form of the gene Myc alters the metabolism of mitochondria, the cell?s powerhouse, making it dependent on the amino acid glutamine for survival. Depriving cells of glutamine selectively induces programmed cell death in cells overexpressing mutant Myc. Using Myc-active neuroblastoma cells, a team three priotein executors of the glutamine-starved cell, representing a downstream target at which to aim drugs. Roughly 25 percent of all neuroblastoma cases are associated with Myc-active cells.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134230.htm

Source: http://www.sciencedaily.com/rss/health_medicine/genes.xml

lottery ticket megga millions what is autism the giver march 30 rimm george h w bush

Holyoke Mayor Ran As Gaming Opponent, Now Supports Casino Bid

HOLYOKE, Mass. (AP) ? A western Massachusetts mayor whose opposition to casino plans helped him win last year?s election at age 22 is now supporting a bid to bring a gambling resort to town.

Holyoke Mayor Alex Morse is expected to announce Monday that he is backing plans for a casino near Interstate 91 on the side of Mount Tom.

Morse says he changed his mind because a casino would be a big boost to the city?s struggling economy. He acknowledges flip-flopping on the issue and is prepared for a backlash, but he says it?s in the best interests of the city.

A 1-year-old law allows up to three resort-style casinos in Massachusetts, but just one in the western part of the state. Three major casino operators have proposed gambling resorts in Springfield.

Copyright 2012 The Associated Press.

Source: http://boston.cbslocal.com/2012/11/25/holyoke-mayor-ran-as-gaming-opponent-now-supports-casino-bid/

casey anthony video diary lamarcus aldridge justin timberlake engaged bluefin tuna jonestown john dillinger carlos zambrano

The 12 Companies Paying Americans The Least: 24/7 Wall St.

24/7 Wall St.:

The gap between rich and poor is well illustrated by the large multi-billion dollar corporations employing thousands of low-wage workers. With the Great Recession over, not only are many of these companies now hitting record profits, but their executive pay remains spectacularly high. Meanwhile, according to a report released by the National Employment Law Project, the current federal minimum wage the workers are often paid, is worth 30% less than it was in 1968 in terms of purchasing power.

Read the whole story at 24/7 Wall St.

"; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/2012/11/25/the-12-companies-paying-a_n_2188137.html

madonna super bowl halftime kelly clarkson super bowl giants super bowl 2012 half time show halftime show 2012 kelly clarkson super bowl 2012 ok go

Travel Insurance Advice Not Always Sound With Cruise Vacations ...

travel insurance

Travel insurance for a cruise vacation is one of those things that experts say we need but is viewed by many travelers as an extra, optional expense. Many try to get the minimum coverage for as cheap as possible. After all, odds are staggeringly against needing to use it. But like most insurance, it seems expensive until we need it. Then? Instant bargain. I found that out first-hand not long ago, spending a nice pile of cash on a simple thumb-crushing injury on board Princess Cruises Grand Princess.

Travel experts seem to agree about two things when it comes to travel insurance: Get it and don't buy it through the cruise line.

"Get it" is universally sound advice. Travel agents typically receive calls from those who did not buy travel insurance but need to cancel their cruise just before sailing for a variety of reasons. They are usually always out of luck and lose most of what they paid.

"Don't buy it from the cruise line" is advice of a more self-serving nature. Third-party insurance programs are big money makers for travel agencies, commonly earning a commission of 20% or more of the cost of that third-party program.

But that advice of not buying travel insurance through the cruise line has another, not mentioned, element that sometimes surprises travelers.

Secondary Benefits-
When it comes to the medical coverage part, travel insurance commonly provides secondary benefits, tapped only after a traveler's primary health insurance has denied a claim or been exhausted. That means for the travel insurance company to pay, a claim must be made with the primary insurance carrier first. Then, whatever they don't pay, should be covered by the third-party insurance. It is a bit of a hassle but in the end the traveler gets reimbursed.

Reimbursement-
It's that "reimbursed" part that catches travelers off guard. They assume that since they have travel insurance, if something goes wrong, they are covered ... as in the travel insurance pays the service provider, if they even think that far ahead. Most don't. In reality, that's often not the case.

Covered Reasons-
First, the claim must be for a covered reason, usually some medical event that happens while on vacation. In my case, we were in rough seas on the Grand Princess with the ship listing a bit from side to side. My thumb just happened to be in the wrong place at the wrong time, caught between a metal doorframe and a metal door. Of the door, doorframe and my thumb, guess which one was out of place when the door shut? It happens.

How It Works-
Off I went to the ship's medical center, a facility fully equipped to handle my injury, much like the emergency room at a major hospital. I was treated immediately, given discharge instructions and pain medication, then sent on my way.

I travel quite a bit and have an annual travel insurance plan from a major insurer just in case something like this would happen. In the end, I suffered no financial loss and was reimbursed for all expenses associated with the injury.

But I had to pay for the medical center services before leaving the ship, then get reimbursed. Had I bought the cruise line insurance, I would have paid nothing. Ever.

What If I Can't Pay?
So what if I was on a cruise, had maxed out my credit cards and had no other sources to tap for up-front payment at the medical center? Do I walk the plank? Wash dishes?

Probably not, but its a good idea to call the travel insurance company, either the company that administers the cruise line insurance or the third-party insurance company and ask one very important question:

"If I buy your insurance, have an injury on my cruise and get treated on the ship, do I have to pay for those services before I get off the ship?"

Knowing the answer can eliminate a rather unpleasant surprise later.

Should I Buy Travelers Insurance? With Jeanenne Tornatore

[Photo Credit: Flickr user Manachar Bandicoot]

Source: http://www.gadling.com/2012/11/24/travel-insurance-advice-not-always-sound-with-cruise-vacations/

andrew luck pro day josh johnson kim kardashian flour matt forte jeremy shockey new orleans saints ireland

Sunday, November 25, 2012

Job: Senior Management Analyst (Change Management and ...

Org. Setting and Reporting

?

Umoja is a continuous organizational transformation, enabling high-quality, cost-effective service delivery for evolving United Nations mandates, anywhere in the world.? By updating skills, harmonizing practices and applying global technology, Umoja maximizes productivity of the UN?s human, financial and material resources.? Umoja transcends organizational, geographical and functional barriers, fostering a culture of transparency, accountability, empowerment, sharing and unity across the United Nations. For more information on Umoja visit:? http://www.unumoja.org.?

The position is located in the Change Management Team of Umoja in the Department of Management in New York. The Senior Management Analyst (Change Management and Organizational Alignment) reports to the Team Lead for Change Management, Umoja.

?

Responsibilities

?

The implementation of Umoja will foster dramatic improvements in the UN?s management of human, financial, and materials resources. Organizational Alignment is one of the three main areas within the overall Organizational Change Management Approach. Organizational Alignment is necessary to prepare the UN for the changes involved in implementing the Umoja solution.? The Senior Management Analyst (Change Management and Organizational Alignment) is responsible for developing the strategy, approach and methodology for the key organizational activities relating to change impact analysis and role management and directing the activities of the team in achieving the objectives.? A key part of the incumbent's responsibilities is role management which involves aligning end-users with To-Be Task-Based Roles so that responsibilities are clear, learning is delivered effectively, and appropriate system security can be established.? Stakeholders (and end-users) will have a clear understanding of critical Umoja solution transition and collaboration points.

The Senior Management Analyst (Change Management and Organizational Alignment) is also responsible for developing, planning and executing the approach to capturing all elements of the extent to which Umoja affects the people, process, and technology of the UN. Change Influence Assessments feed the Change Management activities that provide for an effective transition to operating in the new Umoja solution.

Under the overall guidance of the Change Management Team Lead, the Senior Management Analyst (Change Management and Organizational Alignment) will be responsible for the following duties:

? Establish collaborative partnerships with stakeholders at all levels inside and outside the project, particularly the Office of Human Resources Management and Process Owners;
? Apply role management and change management methodologies and tools to identify the affected user population and assess the impact of the change;
? Advise senior management on all aspects of human resources policies, procedures and substance and provides proactive and innovative approaches to delivery of human resources services as well as to strategic and policy issues.
? Analyze requirements for organization and job design changes as aligned to ERP solution including the assessment of job changes and the need for job classification;
? Design and manage strategies to implement organization and job design changes, including team design, job design, capacity planning and classification of posts;
? Design and implement strategies to manage policy change impacts;
? Design, develop and implement role management and role alignment strategies as aligned to ERP solution;
? Develop strategies for managing the change and inform the training programme accordingly so that training efforts are effectively directed;
? Make best possible use of information technology as an enabler of effective collaboration and on-line collaboration tools;
? Collaborate actively with fellow Change Management team members to integrate the organizational alignment activities with other Change Management initiatives and ensure seamless coordination of all Change Management activities from the end user?s perspective;
? Manage delivery of Umoja?s organizational alignment programme against planned targets and goals; direct team members in the development, implementation, monitoring and assessment of change management activities;
? Collaborate with all Umoja work streams, particularly the Realization Team to engage and leverage their expertise and stakeholder networks;
? Undertake data collection activities to assess the impact of Umoja and formulate plans to facilitate all stakeholders? transition to new ways of working; guide design of data collection instruments; review, analyze and interpret responses, identify problems/issues and prepare conclusions;?
? Lead missions to Duty Stations to assess change impact as well as validate and conduct change management activities;
? Recruit and supervise Subject Matter Experts to develop and execute the organizational alignment activities and its associated deliverables;
? Identify priorities, problems and issues to be addressed and propose corrective actions; liaise with relevant parties; identify and initiate follow-up actions to resolve issues and mitigate risks.
? Perform other duties as required.

?

Competencies

?

Core Competencies:

Professionalism:?
-Knowledge of various aspects of change management and human resources management and specific professional experience in managing the impact of change on jobs and people.? Ability to develop and implement innovative approaches to address change management challenges.?
-Knowledge of human resources policies, practices and procedures and ability to apply them in an organizational setting, particularly job evaluation and job classification under the ICSC guidelines.?
-Demonstrated capability to integrate broader knowledge of organizational change management with the specific strategic and planning requirements of an organizational alignment programme.?
-Ability to work effectively under pressure and to coordinate and deal with complex issues in a timely and decisive manner.?
-Shows pride in work and achievements.
- Demonstrates professional competence and mastery of subject matter.
- Is conscientious and efficient in meeting commitments, observing deadlines and achieving results.
- Is motivated by professional rather than personal concerns.
- Shows persistence when faced with difficult problems or challenges.
- Remains calm in stressful situations.?

Communication:
-Speaks and writes clearly and effectively.
-Listens to others, correctly interprets messages from others and responds appropriately.
-Asks questions to clarify, and exhibits interest in having two-way communication.
-Tailors language, tone, style and format to match the audience.
-Demonstrates openness in sharing information and keeping people informed.

Planning & Organizing:
-Develops clear goals that are consistent with agreed strategies.
-Identifies priority activities and assignments; adjusts priorities as required.
-Allocates appropriate amount of time and resources for completing work.
-Foresees risks and allows for contingencies when planning.
-Monitors and adjusts plans and actions as necessary.
-Uses time efficiently.

Managerial Competencies:
Leadership:
-Serves as a role model that other people want to follow.
-Empowers others to translate vision into results.
-Is proactive in developing strategies to accomplish objectives.
-Establishes and maintains relationships with a broad range of people to understand needs and gain support.
-Anticipates and resolves conflicts by pursuing mutually agreeable solutions.
-Drives for change and improvement; does not accept the status quo.
-Shows the courage to take unpopular stands.
-Provides leadership and takes responsibility for incorporating gender perspectives and ensuring the equal participation of women and men in all areas of work.
-Demonstrates knowledge of strategies and commitment to the goal of gender balance in staffing.

Managing Performance:
-Delegates the appropriate responsibility, accountability and decision-making authority.
-Makes sure that roles, responsibilities and reporting lines are clear to each staff member.
-Accurately judges the amount of time and resources needed to accomplish a task and matches task to skills.
-Monitors progress against milestones and deadlines.
-Regularly discusses performance and provides feedback and coaching to staff.
-Encourages risk-taking and supports creativity and initiative.
-Actively supports the development and career aspirations of staff.
-Appraises performance fairly.

?

Education

?

Advanced university degree (Master?s degree or equivalent) in business administration, human resources management, management, marketing, communications or related field.? A first-level university degree in combination with qualifying experience may be accepted in lieu of the advanced university degree.

?

Work Experience

?

A minimum of ten years of progressively responsible experience in the areas of Organizational Design, Organizational Behavior, Change Management, Human Resources Management, Administrative Services or Training is required.? Experience with managing the implementation of policies with regard to salaries, allowances and conditions of service of both locally recruited and internationally recruited staff at Headquarters and at offices away from Headquarters is required. Experience with assessment of job change impacts, job evaluation and job classification is required.? Experience with large scale implementation of organizational change initiatives or major business transformation projects are desirable.? Experience in leading change management, organizational design and role management initiatives are desirable. Diverse experience within the UN system is also desirable.? Qualifying years of experience are calculated following the receipt of the first level university degree recognised by the United Nations.

?

Languages

?

English and French are the working languages of the United Nations Secretariat. For the post advertised, fluency in oral and written English is required. Knowledge of a second official UN language is desirable.

?

Assessment Method

?

Evaluation of qualified candidates may include an assessment exercise which may be followed by competency-based interview.

?

Special Notice

?

This fixed-term appointment is financed from temporary funding and does not carry any expectancy, legal or otherwise, of renewal or of conversion to any other type of appointment in the Secretariat of the United Nations.

?

United Nations Considerations

?

The United Nations shall place no restrictions on the eligibility of men and women to participate in any capacity and under conditions of equality in its principal and subsidiary organs. (Charter of the United Nations - Chapter 3, article 8). The United Nations Secretariat is a non-smoking environment.

?

No Fee

Source: http://www.internationalpeaceandconflict.org/xn/detail/780588%3ATopic%3A789972?xg_source=activity

paris jackson paris jackson Katherine Jackson Olympics Opening Ceremony Time US weekly amelia earhart Sally Ride