As South by Southwest transforms from a massive tech party to a massive music festival, Twitter has unveiled twitter for Musicians and Artists, a page offering tips on how musicians can use the service to connect with their fans. Even if you're not a world-famous musician, many of the suggestions will be pretty familiar. (Use hashtags! Reply to your fans!) Perhaps the most interesting thing about the page is the theme that Twitter leads with ? that the service represents "the artist's voice empowered":
Epigenetic signatures direct the repair potential of reprogrammed cellsPublic release date: 14-Mar-2012 [ | E-mail | Share ]
Contact: Jessica McGovern jessica.mcgovern@tufts.edu 617-636-6586 Tufts University, Health Sciences Campus
BOSTON (March 14, 2012) A research team has identified epigenetic signatures, markers on DNA that control transient changes in gene expression, within reprogrammed skin cells. These signatures can predict the expression of a wound-healing protein in reprogrammed skin cells or induced pluripotent stem cells (iPSCs), cells that take on embryonic stem cell properties. Understanding how the expression of the protein is controlled brings us one step closer to developing personalized tissue regeneration strategies using stem cells from a patient, instead of using human embryonic stem cells. The study was published in the Journal of Cell Science.
When skin cells are reprogrammed, many of their cellular properties are recalibrated as they aquire stem cell properties and then are induced to become skin cells again. In order for these "induced" stem cells to be viable in treatment for humans (tissue regeneration, personalized wound healing therapies, etc.), researchers need to understand how they retain or even improve their characteristics after they are reprogrammed.
Since the initial discovery of reprogramming, scientists have struggled with the unpredictability of the cells due to the many changes that occur during the reprogramming process. Classifying specific epigenetic signatures, as this study did, allows researchers to anticipate ways to produce cell types with optimal properties for tissue repair while minimizing unintended cellular abnormalities.
The researchers used reprogrammed cells to generate three-dimensional connective tissue that mimics an in vivo wound repair environment. To verify the role of the protein (PDGFRbeta) in tissue regeneration and maintenance, the team blocked its cellular expression, which impaired the cells' ability to build tissue.
"We determined that successful tissue generation is associated with the expression of PDGFRbeta. Theoretically, by identifying the epigenetic signatures that indicate its expression, we can determine the reprogrammed cells' potential for maintaining normal cellular characteristics throughout development," said first author Kyle Hewitt, PhD, a graduate of the cell, molecular & developmental biology program at the Sackler School of Graduate Biomedical Sciences, and postdoctoral associate in the Garlick laboratory at Tufts University School of Dental Medicine (TUSDM).
"The ability to generate patient-specific cells from the reprogrammed skin cells may allow for improved, individualized, cell-based therapies for wound healing. Potentially, these reprogrammed cells could be used as a tool for drug development, modeling of disease, and transplantation medicine without the ethical issues associated with embryonic stem cells," said senior author Jonathan Garlick, DDS, PhD, a professor in the department of oral and maxillofacial pathology and director of the division of tissue engineering and cancer biology at TUSDM.
Jonathan Garlick is also a member of the cell, molecular & developmental biology program faculty at the Sackler School and the director of the Center for Integrated Tissue Engineering (CITE) at TUSDM.
###
Additional authors of the study are Yulia Shamis, MSc, a PhD candidate in the cell, molecular, and developmental biology program at the Sackler School; Elana Knight, BSc, and Avi Smith, BA, both research technicians in the Garlick laboratory; Anna Maione, a PhD student in the cell, molecular & developmental biology program at the Sackler School, and Addy Alt-Holland, PhD, MSc, assistant professor at TUSDM.
This work was supported by grant # DE017413 to Dr. Garlick from the National Institute for Dental and Craniofacial Research, part of the National Institutes of Health.
Hewitt KJ, Shamis Y, Knight E, Smith A, Maione A, Alt-Holland A, Garlick JA. Journal of Cell Science. "PDGFRbeta Expression and Function in Fibroblasts Derived from Pluripotent Cells is Linked to DNA Demethylation" Published online February 17, 2012, doi: 10.1242/jcs.099192.
About Tufts University School of Dental Medicine
Founded in 1868, Tufts University School of Dental Medicine (TUSDM) is committed to leadership in education, patient care, research and community service. Students obtain an interdisciplinary education, integrated with medicine, with access to training in dental specialties. Clinics managed at TUSDM provide quality comprehensive care to more than 18,000 diverse individuals annually, including those requiring special needs. Nationally and internationally, the School promotes health and educational programs and researches new procedures, materials and technologies to improve oral health.
About Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences
Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University are international leaders in innovative medical education and advanced research. The School of Medicine and the Sackler School are renowned for excellence in education in general medicine, biomedical sciences, special combined degree programs in business, health management, public health, bioengineering and international relations, as well as basic and clinical research at the cellular and molecular level. Ranked among the top in the nation, the School of Medicine is affiliated with six major teaching hospitals and more than 30 health care facilities. Tufts University School of Medicine and the Sackler School undertake research that is consistently rated among the highest in the nation for its effect on the advancement of medical science.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Epigenetic signatures direct the repair potential of reprogrammed cellsPublic release date: 14-Mar-2012 [ | E-mail | Share ]
Contact: Jessica McGovern jessica.mcgovern@tufts.edu 617-636-6586 Tufts University, Health Sciences Campus
BOSTON (March 14, 2012) A research team has identified epigenetic signatures, markers on DNA that control transient changes in gene expression, within reprogrammed skin cells. These signatures can predict the expression of a wound-healing protein in reprogrammed skin cells or induced pluripotent stem cells (iPSCs), cells that take on embryonic stem cell properties. Understanding how the expression of the protein is controlled brings us one step closer to developing personalized tissue regeneration strategies using stem cells from a patient, instead of using human embryonic stem cells. The study was published in the Journal of Cell Science.
When skin cells are reprogrammed, many of their cellular properties are recalibrated as they aquire stem cell properties and then are induced to become skin cells again. In order for these "induced" stem cells to be viable in treatment for humans (tissue regeneration, personalized wound healing therapies, etc.), researchers need to understand how they retain or even improve their characteristics after they are reprogrammed.
Since the initial discovery of reprogramming, scientists have struggled with the unpredictability of the cells due to the many changes that occur during the reprogramming process. Classifying specific epigenetic signatures, as this study did, allows researchers to anticipate ways to produce cell types with optimal properties for tissue repair while minimizing unintended cellular abnormalities.
The researchers used reprogrammed cells to generate three-dimensional connective tissue that mimics an in vivo wound repair environment. To verify the role of the protein (PDGFRbeta) in tissue regeneration and maintenance, the team blocked its cellular expression, which impaired the cells' ability to build tissue.
"We determined that successful tissue generation is associated with the expression of PDGFRbeta. Theoretically, by identifying the epigenetic signatures that indicate its expression, we can determine the reprogrammed cells' potential for maintaining normal cellular characteristics throughout development," said first author Kyle Hewitt, PhD, a graduate of the cell, molecular & developmental biology program at the Sackler School of Graduate Biomedical Sciences, and postdoctoral associate in the Garlick laboratory at Tufts University School of Dental Medicine (TUSDM).
"The ability to generate patient-specific cells from the reprogrammed skin cells may allow for improved, individualized, cell-based therapies for wound healing. Potentially, these reprogrammed cells could be used as a tool for drug development, modeling of disease, and transplantation medicine without the ethical issues associated with embryonic stem cells," said senior author Jonathan Garlick, DDS, PhD, a professor in the department of oral and maxillofacial pathology and director of the division of tissue engineering and cancer biology at TUSDM.
Jonathan Garlick is also a member of the cell, molecular & developmental biology program faculty at the Sackler School and the director of the Center for Integrated Tissue Engineering (CITE) at TUSDM.
###
Additional authors of the study are Yulia Shamis, MSc, a PhD candidate in the cell, molecular, and developmental biology program at the Sackler School; Elana Knight, BSc, and Avi Smith, BA, both research technicians in the Garlick laboratory; Anna Maione, a PhD student in the cell, molecular & developmental biology program at the Sackler School, and Addy Alt-Holland, PhD, MSc, assistant professor at TUSDM.
This work was supported by grant # DE017413 to Dr. Garlick from the National Institute for Dental and Craniofacial Research, part of the National Institutes of Health.
Hewitt KJ, Shamis Y, Knight E, Smith A, Maione A, Alt-Holland A, Garlick JA. Journal of Cell Science. "PDGFRbeta Expression and Function in Fibroblasts Derived from Pluripotent Cells is Linked to DNA Demethylation" Published online February 17, 2012, doi: 10.1242/jcs.099192.
About Tufts University School of Dental Medicine
Founded in 1868, Tufts University School of Dental Medicine (TUSDM) is committed to leadership in education, patient care, research and community service. Students obtain an interdisciplinary education, integrated with medicine, with access to training in dental specialties. Clinics managed at TUSDM provide quality comprehensive care to more than 18,000 diverse individuals annually, including those requiring special needs. Nationally and internationally, the School promotes health and educational programs and researches new procedures, materials and technologies to improve oral health.
About Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences
Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University are international leaders in innovative medical education and advanced research. The School of Medicine and the Sackler School are renowned for excellence in education in general medicine, biomedical sciences, special combined degree programs in business, health management, public health, bioengineering and international relations, as well as basic and clinical research at the cellular and molecular level. Ranked among the top in the nation, the School of Medicine is affiliated with six major teaching hospitals and more than 30 health care facilities. Tufts University School of Medicine and the Sackler School undertake research that is consistently rated among the highest in the nation for its effect on the advancement of medical science.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
You haven't lived until you've been threatened by the Nation of Islam...and sometimes, you don't live after the Nation of Islam threaten's your life."
Those were the opening remarks of a segment on Tuesday evening's episode of the Glenn Beck Program in which Glenn revealed how he was threatened by none other than rabid Antisemite Louis Farrakhan -- or at least by his henchmen at The Nation.
The NOI official newspaper wrote over the weekend that?Glenn Beck ?is a minion of the Synagogue of Satan?and as such represents the thinking of those used as their low-level pawns.?
The author continued: ?The Holy Qur?an teaches Muslims to never be the aggressor in word or deed, but if attacked, we fight with those who fight with us.?
Sounds a tad threatening, no?
Glenn responded on his program by taking NOI and Farrakhan to task, exploring the movement and their vitriolic leader's history of violence. He also delved into the reasons why he said Farrakhan and NOI might be a threat to President Obama.
Many will recall the fate that befell Malcolm X once he broke with The Nation.
Watch below as Glenn discusses one of the country's most?notorious?propagators?of hate, bigotry and violence:
Build belief. Become a Leader and treat your Network Marketing/Direct Selling business like a ?real? business.
The best way to real success is belief in ourselves and what we?re doing.? Plug into training with the company, sponsor and success team.??? All training from the company and success team should be free and accessible.
Read success books and listen to CD?s.? Buy them used on Amazon, or go to the library, read or listen to them online.? Go to success events.? They are for your benefit to help you grow into a leader.? Investing in our business (ROI) pays us back tenfold. Constantly be learning and growing.? Become a leader and add value to people?s lives and help them build their business.
Treat your Network Marketing business like a ?real? business. We hear it all the time.? ?I don?t want to tell anyone I know about my Network Marketing business until I see results with the products or until I?m making money.? Do you think that people who invest in and open up a restaurant just sit there and wait to have results before they invite anyone into their business establishment??? If they did this, they?d never open for business.
Put that open for business sign out for your Network Marketing business and shout it out to let everyone what you do?.
Stop blaming others for failure.? We are the captain of our own ship.? Failure is just the rehearsal, success is the main event.?? There will always be obstacles and challenges to overcome with any worthwhile endeavor.? Get over it and keep on taking action that will lead to your success and help you lead others.? When we fail no one is to blame but us.
Besides if everything that goes wrong is always another person?s fault they are the ones growing through the adversity and reaping the rewards of leadership right??? When we?re not failing we?re not growing forward for success.
I spoke more about this on the Million Dollar Year Hot Seat training recently.? Here?s the link to listen to that audio training ? http://bit.ly/wo3nkI
Sue is a Network Marketing professional and business owner who has been networking, connecting and building relationships online since 1996.? She has created a full time career in Network Marketing and lives at Lake Travis in Austin Texas with her husband and two sons.? Co-author of the Direct Selling Women?s Alliance book ?Build It Big? ? 101 Insider Secrets From Top Direct Selling Experts & trainer on their Mentored By The Master Series CD and contributing writer for The Network Marketing Business Journal, Home Business Magazine and TheNetworkMarketingMagazine.com.? She is passionate about helping others to achieve success in their business and interested in health/wellness/fitness and living a gluten free lifestyle.? Find out more on her blog at ? http://www.sueseward.com
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Posted: March 13th, 2012 | Author: BohincYuricic721 | Filed under: The Main Course | Tags: advice, business, career, computer, education, general, how to, internet, learn, marketing, misc, miscellaneous, news, review, self, software, tech, training, uncategorized, web, work | Comments Off
If you?re thinking about an excellent career in supporting networks then the MCSA course will suit you perfectly. Whether you?re about to get into IT or already have experience but need a professional certificate, there?s a range of courses to fulfil your needs. To achieve certification at the MCSA level there are four MCP?s (Microsoft Certified Professional exams) needed to be passed. If you?re new to IT, it?s likely you?ll have to pick up some skills prior to tackling the first of the four MCP?s. Identify a training company that has a team of advisors who can help you sort out the best way forward for you and can match a course start point to your current skill set.
Accredited exam preparation and simulation materials are essential ? and should definitely be sought from your training provider. Because a lot of IT examining boards are from the USA, you need to become familiar with their phraseology. It isn?t good enough just going through the right questions ? they have to be in the same format as the actual exams. Why don?t you check whether you?re learning enough by doing quizzes and mock ups of exams before you take the real thing.
The sometimes daunting task of finding your first role in IT can be made easier by training colleges, through a Job Placement Assistance service. Don?t get caught up in this feature ? it?s quite easy for training companies to overstate it?s need. In reality, the massive skills shortage in this country is what will enable you to get a job.
CV and Interview advice and support is sometimes offered (alternatively, check out one of our sites for help). Make sure you update that dusty old CV straight away ? not after you?ve qualified! You may not have got to the stage where you?ve got to the exam time when you will be offered your first junior support job; yet this won?t be the case unless you?ve posted your CV on job sites. If you don?t want to travel too far to work, then you may well find that a specialist locally based employment agency could serve you better than a national service, for they are much more inclined to know the local job scene.
A constant frustration of some training providers is how hard men and women are prepared to study to become certified, but how ill-prepared they are to market themselves for the job they?re qualified for. Get out there and hustle ? you might find it?s fun. Consider www.mcsa-course.co.uk for current facts.
Sometimes, individuals don?t catch on to what information technology is all about. It is ground-breaking, exciting, and puts you at the fore-front of developments in technology that will change our world over the next few decades. Technology, computers and connections via the internet will radically shape our lives over the coming years; profoundly so.
And keep in mind that income in the IT market throughout this country is significantly better than the national average salary, which means you will more than likely receive a lot more with professional IT knowledge, than you would in most typical jobs. Due to the technological sector emerging at an unprecedented rate, it?s predictable that the need for qualified professionals will flourish for the significant future.
Hop over to this website for logical tips: MCTS SQL and Part P Career Courses.
As South by Southwest transforms from a massive tech party to a massive music festival, Twitter has unveiled twitter for Musicians and Artists, a page offering tips on how musicians can use the service to connect with their fans. Even if you're not a world-famous musician, many of the suggestions will be pretty familiar. (Use hashtags! Reply to your fans!) Perhaps the most interesting thing about the page is the theme that Twitter leads with ? that the service represents "the artist's voice empowered":
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Public release date: 14-Mar-2012
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